IPSEs IN THE LAST 24H
  • Alon Liel
    Alon Liel “The move [Egypt joining South Africa's ICJ genocide case against Israel] is an unbelievable diplomatic blow to Israel. Egypt is the cornerstone of our standing in the Middle East. The connections that Israel has in the Middle East and North Africa today, including with Jordan, the UAE and Morocco, is all a result of what Egypt did 40 years ago. With Egypt joining South Africa now in The Hague, it's a real diplomatic punch. Israel would have to take it very seriously. This is what I have been warning about. It's coming from several directions. Israel has to … listen to the world - not only to the Israeli public opinion asking now for revenge. We have to look overall in the wider picture, in the long-term security of Israel, not only in the next few weeks in Gaza.” 6 hours ago
  • Franz-Stefan Gady
    Franz-Stefan Gady “The Russians have understood, just as a lot of analysts have, that the major disadvantage that Ukraine is currently suffering from is manpower. By thinning out the frontline, you are increasing the odds of a breakthrough.” 9 hours ago
  • Oleksandr Syrskyi
    Oleksandr Syrskyi “This week, the situation in Kharkiv Oblast deteriorated substantially. Currently, there are continuing battles along the state's border with Russia. The situation is challenging, but the Defence Forces are doing everything possible to maintain defensive lines and positions, resulting in defeat for the adversary.” 9 hours ago
  • John Kirby
    John Kirby “It is possible that Russia will make further advances in the coming weeks, but we do not anticipate any major breakthroughs, and over time, the influx of U.S. assistance will enable Ukraine to withstand these attacks over the course of 2024.” 10 hours ago
  • Volker Türk
    Volker Türk “I can see no way that the latest evacuation orders, much less a full assault, in an area with an extremely dense presence of civilians, can be reconciled with the binding requirements of international humanitarian law and with the two sets of binding provisional measures ordered by the International Court of Justice.” 10 hours ago
  • Volodymyr Zelenskiy
    Volodymyr Zelenskiy “It is important that partners support our soldiers and Ukrainian stability with timely supplies. Really timely. The package that really helps is the weapons brought to Ukraine, not just the ones announced.” 23 hours ago
  • Oleh Syniehubov
    Oleh Syniehubov “We clearly understand what forces the enemy is using in the north of our territory. Certainly, the escalation can grow, the pressure can increase, it can strengthen its military units, its military presence. As of now the enemy keeps pressing in the north of our region. Our forces have repelled nine attacks.” 23 hours ago
View All IPSEs inserted in the Last 24h

#Mutations

Page with all the IPSEs stored in the archive with the tag #Mutations linked to them.
The IPSEs are presented in chronological order based on when the IPSEs have been pronounced.

“Less than 0.1% each of the sequences uploaded to platforms like GISAID have been Alpha, Beta and Gamma. 96% of the sequences available are still Delta. About 1.6% of sequences that have been shared in recent weeks is Omicron. We definitely see increasing growth rates of Omicron where it's been detected and it's now been reported in more than 106 countries to date. There is a combination of factors that we think are leading to this increasing transmission. First are the mutations that are identified in the Omicron variant and we know something about these mutations because some of these are present in other variants of concern. So, for example, in Omicron there are mutations that allow the virus to adhere to the cell more easily and infect the cell more easily. We also see immune escape where we see increasing rates of reinfection. And then there is some preliminary data that's looking at the efficiency and replication of the Omicron variant in the upper respiratory tract as opposed to the lower respiratory tract in the lungs. So this combination of factors is likely leading to why we are seeing increased growth rates in a number of countries.”

author
World Health Organization (WHO) epidemiologist
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“The number of mutations per se does not mean that the new variant will cause any problems; although it may make it more likely to look different to the immune system.”

author
Former chair of the British Medical Association's Public Health Medicine Committee
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“WHO recommends that countries continued to apply a risk-based and a scientific approach when implementing travel measures … implementing travel measures is being cautioned against. Researchers are working to understand more about the mutations and what they potentially mean for how transmissible or virulent this variant [B.1.1.529] is.”

author
Spokesman for World Health Organization (WHO)
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“Worth emphasising this is at super low numbers right now in a region of Africa that is fairly well sampled, however it very very much should be monitored due to that horrific spike profile (would take a guess that this would be worse antigenically than nearly anything else about). A final observation - this variant contains not one, but two furin cleavage site mutations - P681H (seen in Alpha, Mu, some Gamma, B.1.1.318) combined with N679K (seen in C.1.2 amongst others) - this is the first time I've seen two of these mutations in a single variant.”

author
Virologist at the Imperial College London
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“While vaccines have been pledged for donation from all donors, we are not getting the vaccines into people's arms and urgently need a month-to-month timetable to meet our interim targets and prevent further loss of lives. An immediate emergency airlift of 240m vaccines this month from the global north to the global south should be followed by the transfer of a further 760m vaccines transferred by February. This would be the biggest peacetime public policy decision, which could save 100,000 lives and prevent many of the one million Covid-induced deaths projected over the next year. Vital time to contain Covid, stop mutations and save lives is being wasted. It needs our political leaders to step up to the sign-off. Every passing day is a day lost in the battle to contain Covid and save lives. As long as health workers remain unvaccinated and the vulnerable elderly have no protection against Covid-19, deaths in the poorest countries will rise, and there the disease threatens to spread uninhibited in unprotected environments, giving rise to new variants that could eventually infect even the fully vaccinated.”

author
Former Prime Minister of the UK and adviser to the World Health Organization
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“The more the virus circulates, the more likely it is that mutations and variants will emerge, which could make our current vaccines ineffective. At the same time, poor countries are being left behind without vaccines and basic medical supplies like oxygen. As we've learned, viruses don't care about borders. We have to vaccinate as many people as possible, everywhere in the world, as quickly as possible. Why wait and watch instead of getting ahead of this?”

author
Professor of global public health at the University of Edinburgh
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“Mutations occur much more frequently with RNA viruses because the RNA has no 'proofreading' capacity and, as such, cannot correct the mistakes that are made during viral replication. This can then become problematic when the virus then selects for mutations that allows for the virus to replicate more efficiently. For example, if a person has been previously infected, then the virus may select for mutations that can evade that previous immunity, or select for mutations that allow for the virus to be more transmissible. The variants do not appear to make the coronavirus disease more deadly. The variants do, however, make the virus more transmissible. This could mean that more people can become infected more rapidly - and thus still overburdening healthcare systems.”

author
Assistant professor at the Boston University School of Public Health
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