IPSE'S AUTHORS LAST 24h
Check all the Authors in the last 24h
IPSEs IN THE LAST 24H
  • Joe Biden
    Joe Biden “It's a humanitarian crisis in Gaza. I am working on a deal to end the fighting and build a lasting and durable peace. Leadership is about fighting through the most intractable problem. It's about channeling anger, frustration and heartbreak to find a solution. It's about doing what you believe is right, even when it's hard and lonely.” 16 hours ago
  • Sylvain Ekenge
    Sylvain Ekenge “An attempted coup d'etat has been put down by the defence and security forces. The attempt involved foreigners and Congolese. These foreigners and Congolese have been put out of action, including their leader.” 19 hours ago
  • Martin Griffiths
    Martin Griffiths “When very, very experienced humanitarian aid workers, who have been in all kinds of places around the world for decades, when they go to Gaza - to help, to serve, to work - it is traumatising for them. So, God help what it must be for the people of Gaza. It is really difficult and it's getting worse daily. We meet with Israelis daily through COGAT, the committee set up for this purpose. We have many detailed discussions with them about security, about the movement of our trucks and convoys, about the priorities for fuel, but the fact of the matter is, we are not in a position to provide proper aid to the people of Gaza. Right now, it's not ever been quite as difficult as it is today. Much more can be done and ideally, obviously and hopefully this [Israeli military] operation needs to stop.” 19 hours ago
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#Mutations

Page with all the IPSEs stored in the archive with the tag #Mutations linked to them.
The IPSEs are presented in chronological order based on when the IPSEs have been pronounced.

“Less than 0.1% each of the sequences uploaded to platforms like GISAID have been Alpha, Beta and Gamma. 96% of the sequences available are still Delta. About 1.6% of sequences that have been shared in recent weeks is Omicron. We definitely see increasing growth rates of Omicron where it's been detected and it's now been reported in more than 106 countries to date. There is a combination of factors that we think are leading to this increasing transmission. First are the mutations that are identified in the Omicron variant and we know something about these mutations because some of these are present in other variants of concern. So, for example, in Omicron there are mutations that allow the virus to adhere to the cell more easily and infect the cell more easily. We also see immune escape where we see increasing rates of reinfection. And then there is some preliminary data that's looking at the efficiency and replication of the Omicron variant in the upper respiratory tract as opposed to the lower respiratory tract in the lungs. So this combination of factors is likely leading to why we are seeing increased growth rates in a number of countries.”

author
World Health Organization (WHO) epidemiologist
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“The number of mutations per se does not mean that the new variant will cause any problems; although it may make it more likely to look different to the immune system.”

author
Former chair of the British Medical Association's Public Health Medicine Committee
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“WHO recommends that countries continued to apply a risk-based and a scientific approach when implementing travel measures … implementing travel measures is being cautioned against. Researchers are working to understand more about the mutations and what they potentially mean for how transmissible or virulent this variant [B.1.1.529] is.”

author
Spokesman for World Health Organization (WHO)
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“Worth emphasising this is at super low numbers right now in a region of Africa that is fairly well sampled, however it very very much should be monitored due to that horrific spike profile (would take a guess that this would be worse antigenically than nearly anything else about). A final observation - this variant contains not one, but two furin cleavage site mutations - P681H (seen in Alpha, Mu, some Gamma, B.1.1.318) combined with N679K (seen in C.1.2 amongst others) - this is the first time I've seen two of these mutations in a single variant.”

author
Virologist at the Imperial College London
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“While vaccines have been pledged for donation from all donors, we are not getting the vaccines into people's arms and urgently need a month-to-month timetable to meet our interim targets and prevent further loss of lives. An immediate emergency airlift of 240m vaccines this month from the global north to the global south should be followed by the transfer of a further 760m vaccines transferred by February. This would be the biggest peacetime public policy decision, which could save 100,000 lives and prevent many of the one million Covid-induced deaths projected over the next year. Vital time to contain Covid, stop mutations and save lives is being wasted. It needs our political leaders to step up to the sign-off. Every passing day is a day lost in the battle to contain Covid and save lives. As long as health workers remain unvaccinated and the vulnerable elderly have no protection against Covid-19, deaths in the poorest countries will rise, and there the disease threatens to spread uninhibited in unprotected environments, giving rise to new variants that could eventually infect even the fully vaccinated.”

author
Former Prime Minister of the UK and adviser to the World Health Organization
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“The more the virus circulates, the more likely it is that mutations and variants will emerge, which could make our current vaccines ineffective. At the same time, poor countries are being left behind without vaccines and basic medical supplies like oxygen. As we've learned, viruses don't care about borders. We have to vaccinate as many people as possible, everywhere in the world, as quickly as possible. Why wait and watch instead of getting ahead of this?”

author
Professor of global public health at the University of Edinburgh
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“Mutations occur much more frequently with RNA viruses because the RNA has no 'proofreading' capacity and, as such, cannot correct the mistakes that are made during viral replication. This can then become problematic when the virus then selects for mutations that allows for the virus to replicate more efficiently. For example, if a person has been previously infected, then the virus may select for mutations that can evade that previous immunity, or select for mutations that allow for the virus to be more transmissible. The variants do not appear to make the coronavirus disease more deadly. The variants do, however, make the virus more transmissible. This could mean that more people can become infected more rapidly - and thus still overburdening healthcare systems.”

author
Assistant professor at the Boston University School of Public Health
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